The article examines the essence and significance of the phenomenon of mismatch in skills and qualifications as a generalizing concept that combines all types of gaps and imbalances in skills and qualifications. Different types of this mismatch are considered. The factors that determine the spread of this phenomenon have been identified. The danger of widening the gaps in qualifications and skills, which manifests itself in the negative impact on the formation of qualitative characteristics of human capital and causes inefficiency in the use of its potential is substantiated. Through the prism of human capital, potential threats and global challenges caused by skills mismatches and their implications for society, employers and employees have been identified. Based on the analysis of increasing mismatch in skills and qualifications of workers, the formation of current trends in the global labor market has been examined; and these trends are: the existence of the so-called "post-pandemic hiking workers freezing syndrome" as an imbalance between supply and demand for jobs provoked by the COVID-19 pandemic; deepening the mismatch between the level of working people education and the jobs they occupy, indicating a significant global gap between education and employment. Possible ways to overcome skills and qualifications mismatches include strengthening the role of employers in deciding this issue and using the Future Skills Architect practical set of instruments, where the key indicator is the country's maturity index (FSA), which will enable governments of countries to form sets of quality solutions in the struggle for human capital.